Efficacy of a combination modified-live IBR-BVD-PI3- BRSV vaccine + Mannheimia haemolytica toxoid against challenge with virulent bovine respiratory syncytial virus (BRSV) in young calves 60 days of age
Bibliographic record
Abstract
Efficacy of attenuated (att) bovine respiratory syncytial virus (attBRSV) as an antigen fraction in a multivalent 6-way vaccine containing modified-live virus and an inactivated Mannheimia haemolytica bacterin-toxoid was given as a single subcutaneous injection, and evaluated by an aerosol challenge by nebulization in young calves with virulent BRSV strain 21 d after vaccination. A total of 32 Holstein calves, seronegative to BRSV and 60 days-of-age at the time of vaccination, were used in the study. Calves were allocated to 2 treatment groups with 16 animals per group, and received either a single dose of a modified-live bovine herpes virus-1, bovine viral diarrhea virus, parainfluenza 3 virus, bovine respiratory syncytial virus vaccine + M. haemolytica bacterin-toxoid, or corresponding placebo formulation without targeted BRSV antigen. Administration of the 6-way vaccine containing BRSV fraction induced significantly higher virus-neutralizing antibody (p=0.0003) and anti-BRSV IgG titers (p=0.0006) in vaccinated animals compared to the placebo group. Consequently, BRSV-vaccinated calves had significantly (p<0.0001) higher arterial partial pressures of oxygen (PaO2), significantly (p<0.0001) lower percentage of lung lesions, and significantly reduced mortality rate (p<0.0001) than did placebo vaccinated calves subsequent to BRSV challenge. Furthermore, there was a 61.2% reduction in virus shedding and duration of shedding (p<0.0001), indicating strong vaccine efficacy.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".