Tailoring the mechanoresponsive release from silica nanocapsules
Bibliographic record
Abstract
Triggering the release of encapsulated cargos using mechanical stress acting on a nanocarrier is a strategy with potential applications from drug delivery to self-healing coatings. The mechanically triggered release of encapsulated molecules can be controlled by tuning the mechanical properties of the nanocapsules, which are strongly linked to the nanocapsule architecture. Here, silica nanocarriers were designed to tune precisely the release initiated by mechanical stress. We synthesized silica nanocapsules (SiNCs) with a finely tunable diameter and shell thickness and performed AFM nanoindentation experiments to determine the breaking force of single SiNCs. We demonstrated that it is possible to trigger the release of encapsulated payload by the application of an external mechanical force on the SiNCs. Furthermore, we successfully controlled the breaking force and the amount of released payload by tailoring the architecture of the nanocarriers, illustrating how such mechanoresponsive SiNCs could be used as responsive nanocarriers for the delivery of molecular cargos.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".