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Record W3198518576 · doi:10.1016/j.ebiom.2021.103563

A holistic approach to predicting diabetes risk via biomarkers

2021· letter· en· W3198518576 on OpenAlexaff
Alan A. Cohen

Bibliographic record

VenueEBioMedicine · 2021
Typeletter
Languageen
FieldMedicine
TopicBody Composition Measurement Techniques
Canadian institutionsUniversité de SherbrookeCentre Hospitalier Universitaire de Sherbrooke
Fundersnot available
KeywordsMahalanobis distanceContext (archaeology)OperationalizationPsychologyMedicineBioinformaticsEpistemologyBiologyPhilosophyArtificial intelligenceComputer science

Abstract

fetched live from OpenAlex

Leo Tolstoy's novel Anna Karenina starts with the famous line, “All happy families are alike; each unhappy family is unhappy in its own way.” This “Anna Karenina Principle” has been applied in numerous contexts, including ecological risk assessment, microbiomes, economics, and many others. In physiology and health, we might rephrase it as a hypothesis; “All healthy physiologies are healthy in relatively standard ways, but there are limitless ways in which physiology can go awry.” This hypothesis raises interesting corollaries: to what extent is there a general, unique profile of physiological “health,” which might be perturbed in a multiplicity of ways? Can we understand health as the body's ability to maintain such a homeostatic state, or more broadly its dynamic equilibrium? Might having an overall profile that is far from average be an indicator either of a specific but undiagnosed pathology, or of a general lack of resiliency predisposing the individual to higher risks of a host of adverse outcomes?

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.008
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Theoretical or conceptual · Consensus signal: none
GenreCandidate signal: Commentary · Consensus signal: none
Teacher disagreement score0.005
Threshold uncertainty score0.016

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0030.008
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0020.001
Bibliometrics0.0050.003
Science and technology studies0.0010.001
Scholarly communication0.0050.003
Open science0.0010.003
Research integrity0.0020.003
Insufficient payload (model declined to judge)0.0030.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.040
GPT teacher head0.278
Teacher spread0.238 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designTheoretical or conceptual
Domainnot available
GenreCommentary

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2021
Admission routes1
Has abstractyes

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