The Effects of Nitroglycerin on the Oxytocin Dose-response Profile in Oxytocin-desensitized and Naive Human Myometrium: An In Vitro Study
Bibliographic record
Abstract
(Anesth Analg. 2021;132:231–239) During delivery, nitroglycerin is used clinically to reduce uterine tone, in situations such as uterine hyperstimulation or difficult fetal extraction. Oxytocin (OT) is an uterotonic used to induce contractions and after delivery to prevent postpartum hemorrhage. OT exposure in myometrium can cause desensitization of OT receptors. A previous study by Lau et al1 found OT can achieve satisfactory uterine tone following the use of nitroglycerin myometrium in vitro, but it is not clear if the use of nitroglycerin affects the dose needed to reestablish uterine tone. This in vitro study investigates whether nitroglycerin alters the OT dose-response in OT-desensitized and OT-naive tissues.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".