Autophagy in major human diseases
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Abstract
Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy-related processes cause severe human pathologies. Here, we review and discuss preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, infectious, musculoskeletal, and ocular disorders.
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The record
- Venue
- The EMBO Journal
- Topic
- Autophagy in Disease and Therapy
- Field
- Medicine
- Canadian institutions
- University of British Columbia
- Funders
- National Institute of General Medical SciencesKenneth Rainin FoundationNational Cancer InstituteCancer Research UKBiotechnology and Biological Sciences Research CouncilNational Institute of Allergy and Infectious DiseasesKennedy Trust for Rheumatology ResearchWellcome TrustBristol-Myers SquibbAstraZenecaPfizerNational Institute on Aging
- Keywords
- BiologyAutophagyVirologyComputational biologyGeneticsApoptosis
- Has abstract in OpenAlex
- yes