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Cannabinoids in the rheumatic diseases

2021· article· en· W3199493074 on OpenAlexaff
Mary‐Ann Fitzcharles

Bibliographic record

VenueRevista Paulista de Reumatologia · 2021
Typearticle
Languageen
FieldMedicine
TopicCannabis and Cannabinoid Research
Canadian institutionsMcGill University Health Centre
Fundersnot available
KeywordsMedicineRheumatologyFibromyalgiaCannabisIntensive care medicineInternal medicineLegalizationAlternative medicinePhysical therapyPsychiatryPathology

Abstract

fetched live from OpenAlex

Pain is a prevalent symptom for rheumatology patients. Even when inflammatory arthritis is well controlled, remaining pain or comorbid fibromyalgia is a cause of persistent suffering. As current treatments for pain management are suboptimal, patients are increasingly exploring medical cannabis as a treatment option, with interest bolstered by legalization of both medical and recreational cannabis is many jurisdictions. This easier access to cannabis may even prompt some patients to experiment with use and self-medicate. Although the clinical evidence for effect of cannabinoids in rheumatology management is mostly lacking, rheumatologists must be sufficiently knowledgeable to provide patients with evidence-based information about effects and harms. This review will address the pharmacological properties of medical cannabis, products available, and methods of administration and will highlight considerations applicable for use in various rheumatology patient populations. Medical cannabis may provide some symptom relief for some rheumatology patients, but with caution about known short-term risks and largely unknown long-term risks. Medical cannabis may finally emerge as a treatment option for these patients. Even in the present setting of limited evidence, clinicians must understand the popular advocacy for medical cannabis and play an active role to ensure competent and safe patient care. Keywords: Rheumatic pain. Cannabinoids.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.004
Threshold uncertainty score0.014

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0020.001
Science and technology studies0.0010.001
Scholarly communication0.0010.001
Open science0.0000.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0040.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.015
GPT teacher head0.304
Teacher spread0.289 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2021
Admission routes1
Has abstractyes

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