3D shearlet-based descriptors combined with deep features for the classification of Alzheimer's disease based on MRI data
Bibliographic record
Abstract
Alzheimer's disease (AD) is a neurodegenerative disease that afflicts millions of people worldwide. Early detection of AD is critical, as drug trials show a promising advantage to those patients with early diagnoses. In this study, magnetic resonance imaging (MRI) datasets from the Alzheimer's Disease Neuroimaging Initiative (ADNI) and The Open Access Series of Imaging Studies are used. Our method for performing the classification of AD is to combine a set of shearlet-based descriptors with deep features. A major challenge in classifying such MRI datasets is the high dimensionality of feature vectors because of the large number of slices of each MRI sample. Given the volumetric nature of the MRI data, we propose using the 3D shearlet transform (3D-ST), but we obtain the average of all directionalities, which reduces the dimensionality. On the other hand, we propose to leverage the capabilities of convolutional neural networks (CNN) to learn feature maps from stacked MRI slices, which generate a very compact feature vector for each MRI sample. The 3D-ST and CNN feature vectors are combined for the classification of AD. After the concatenation of the feature vectors, they are used to train a classifier. Alternatively, a custom CNN model is utilized, in which the descriptors are further processed end to end to obtain the classification model. Our experimental results show that the fusion of shearlet-based descriptors and deep features improves classification performance, especially on the ADNI dataset.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".