ANTI-CARCINOGENIC POSSESSIONS OF CITRUS PEEL EXTRACT AND FLAVONOIDS
Bibliographic record
Abstract
Researchers and scientists synthesized numerous drugs and medications to treat cancer. These synthesized drugs related with many side reactions could deteriorate the quality of patient's life. Recently, various functional foods containing effective molecular components against cancer has gained much popularity as no side effects are associated with them and these are natural based product could be easily consumed and can left a long-lasting health impression on the life of patients. Citrus peel enriched with flavonoids, polymethoxylated flavones and numerous bioactive components demonstrated anti-carcinogenic, anti-tumour, anti-proliferative and anti-inflammatory activities on skin cancer, gastric cancer, prostate cancer, oseophageal tumorigenesis, colon carcinogenesis, colorectal carcinoma cell, human squamous cell carcinoma and against human cancer cell lines. A novel functional natural product named Gold Lotion (GL) was formulated from citrus peel extract to inhibit the inflammation-associated tumorigenesis. Gold Lotion (GL) demonstrated a clear and promising strategy by in vivo analysis and result showed beneficial aspects to treat prostate cancer, skin cancer and colon cancer in mice. Six different orange peel extracts (OPEs) were prepared containing bioactive potential of polymethoxyflavones (PMFs) and hydroxylated PMFs (OH-PMFs). In vitro study of citrus flavonoids effects on the growth of a human squamous cell carcinoma cell line (HTB43) demonstrated the health benefit and anti-cancer effects by examination of four plant flavonoids (taxifolin, nobiletin, quercetin and tangeretin). Moreover, quercetin chalcone (QC) and pH-modified citrus pectin (MCP) are the modified substances of quercetin (a flavonoid) and citrus pectin (a polysaccharide found in the cell wall of plants). Earlier studies indicated that many antitumor properties due to immune stimulation, free radical scavenging, alteration of the mitotic cycle in tumor cells; gene expression modification, anti-angiogenesis activity and apoptosis induction are exhibited by quercetin. Prostate cancer and melanoma metastases can also be inhibited by modified citrus pectin (MCP).
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".