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Record W3202495714 · doi:10.1371/journal.pmed.1003747

Evaluation of portable devices for medicine quality screening: Lessons learnt, recommendations for implementation, and future priorities

2021· article· en· W3202495714 on OpenAlexfundno aff
Céline Caillet, Serena Vickers, Vayouly Vidhamaly, Kem Boutsamay, Phonepasith Boupha, Stephen Zambrzycki, Nantasit Luangasanatip, Yoel Lubell, Facundo M. Fernández, Paul N. Newton

Bibliographic record

VenuePLoS Medicine · 2021
Typearticle
Languageen
FieldMedicine
TopicPharmaceutical Quality and Counterfeiting
Canadian institutionsnot available
FundersUniversity of OxfordDepartment of Foreign Affairs and Trade, Australian GovernmentAustralian GovernmentWellcome TrustWellcomeGovernment of the United KingdomDepartment for International DevelopmentUnited States PharmacopeiaGovernment of CanadaAsian Development Bank
KeywordsQuality (philosophy)MedicineMEDLINEMedical physicsComputer scienceData sciencePolitical science

Abstract

fetched live from OpenAlex

Portable devices able to detect substandard and falsified medicines are vital innovations for enhancing the inspection of medicines in pharmaceutical supply chains and for timely action before they reach patients. Such devices exist, but there has been little to no independent scientific evidence of their accuracy and cost-effectiveness to guide regulatory authorities in choosing appropriate devices for their settings.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.162
metaresearch head score (Gemma)0.252
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.162
Threshold uncertainty score0.856

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.1620.252
Meta-epidemiology (narrow)0.0030.001
Meta-epidemiology (broad)0.0040.004
Bibliometrics0.0020.003
Science and technology studies0.0020.004
Scholarly communication0.0120.015
Open science0.0070.005
Research integrity0.0110.009
Insufficient payload (model declined to judge)0.0110.002

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.508
GPT teacher head0.571
Teacher spread0.063 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations17
Published2021
Admission routes1
Has abstractyes

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