A Marine Natural Products as Modulators of Multidrug Resistance
Bibliographic record
Abstract
Multidrug resistance (MDR) which enable the tumor cells to possess intrinsic or acquired cross resistance to multiple chemotherapeutic agents simultaneously is considered to be a major challenge in cancer chemotherapy during the 21st century. numerous efflux pumps and transport proteins have been found to play important roles in MDR either the phenomenon of lowering the total intracellular retention of chemotherapeutic drugs or the redistribution of intracellular accumulation of drugs away from target organelles are two of the basic mechanisms involved in this process of MDR by transmembrane proteins which are expressed in varying concentrations in different neoplasms. Multiple compounds that have the potential to inhibit these pumps or proteins can be a future prospective for adjuvant treatment of neoplastic conditions. In this regard, compounds derived from natural products bear the advantages of low-cost and relative nontoxicity thus providing a great pool of lead structures for chemical derivatizations. This review gives an overview on chemical substances isolated from natural products of marine origin which possess the MDR modulating properties
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".