Assessment of Magnesium Levels in Ischemic Cerebral Stroke Patients and Its Correlation with Severity of Neurological Disability – A Longitudinal Observational Study from Sri Amritsar, Punjab
Bibliographic record
Abstract
BACKGROUND World Health Organization (WHO) clinically defines a stroke as ‘the rapid development of clinical signs and symptoms of a focal neurological disturbance lasting more than 24 hours or leading to death with no apparent cause other than vascular origin’. Hypo magnesia (ionized form) leads to neuromuscular hyperirritability, tremors, increased vascular resistance, coronary vasospasm and hypertension. Magnesium deficiency triggers vasoconstriction enhancing vascular endothelial injury and hence leads to atherosclerosis. In the present study, we wanted to evaluate serum magnesium levels in ischemic cerebral stroke patients and correlate its severity with the neurological disability using modified Rankin scale (mRS) and Canadian neurological scale. METHODS It was a longitudinal observational study, undertaken in the Department of Medicine in Sri Guru Ram Das Institute of Medical Sciences and Research, Sri Amritsar from December 2018 to June 2020. 60 patients with acute ischemic cerebral stroke fulfilling the inclusion criteria were selected. 5 ml venous sample for serum magnesium level was taken within 24 hours and on day 5 of admission. Presence or absence of hypomagnesemia in patients after acute cerebral ischemic stroke was recorded during the hospital stay of patients, receiving standard management protocol of ischemic stroke. The correlation co-efficient of serum magnesium level with modified Rankin scale and Canadian neurological scale was calculated. RESULTS The mean age of patients was 61.6 ± 1.6 years, 42 (70 %) patients were male and 18 (30 %) were females and there was male preponderance. The mean serum magnesium level was measured as 1.78 ± 0.2 mg/dL, it was observed that the mean value for mRS was 3.93 ± 0.75 and Canadian neurological scale was 7.11 ± 2.01 within 24 hours and on the 5th day the mean value for mRS was 3.5 ± 1.09 and Canadian neurological scale was 8.02 ± 2.97. The present study observed a statistically significant correlation between mRS score and serum magnesium level as well as Canadian neurological scale and serum magnesium levels. CONCLUSIONS It was concluded through the results of this study that low levels of magnesium in the body can cause more severe stroke. KEYWORDS Stroke, Serum Magnesium, Hypomagnesemia, Modified Rankin Scale, Canadian Neurological Scale
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".