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Record W3205777260 · doi:10.1056/nejme2114645

Aquaporin-1 Expression and Ultrafiltration of the Peritoneal Membrane

2021· letter· en· W3205777260 on OpenAlexaff
Daniel G. Bichet

Bibliographic record

VenueNew England Journal of Medicine · 2021
Typeletter
Languageen
FieldMedicine
TopicDialysis and Renal Disease Management
Canadian institutionsHôpital du Sacré-Cœur de Montréal
Fundersnot available
KeywordsUltrafiltration (renal)Peritoneal dialysisMembraneOsmosisOncotic pressureSemipermeable membraneMedicineChromatographyTonicityColloidAquaporinReverse osmosisOsmotic pressureInternal medicineBiochemistryChemical engineeringChemistryAlbuminPhysiology

Abstract

fetched live from OpenAlex

Peritoneal dialysis in adults involves diffusion and osmosis through a peritoneal membrane, measuring 1 m2, that is highly vascularized (flow rate, 100 to 150 ml per minute) and has a total available capillary surface area of approximately 2 m2.1 For decades, glucose has been used as the prototypical crystalloid osmotic agent to drive water removal in peritoneal dialysis.2 Glucose is a small osmotic agent (molecular weight, 180 g per mole) that is prone to crystallization but easily diffuses across semipermeable membranes; hence, it is known as a crystalloid substance. In contrast, colloid and noncrystalline substances are retained by membranes because . . .

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.006
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Commentary · Consensus signal: Commentary
Teacher disagreement score0.009
Threshold uncertainty score0.016

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.006
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0000.000
Science and technology studies0.0010.001
Scholarly communication0.0010.001
Open science0.0000.000
Research integrity0.0090.007
Insufficient payload (model declined to judge)0.0030.002

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.017
GPT teacher head0.252
Teacher spread0.235 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreCommentary

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations5
Published2021
Admission routes1
Has abstractyes

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