The Development of B-Adrenergic Blocking Drugs for Management of Primary Open-Angle Glaucoma
Bibliographic record
Abstract
In the last few years, there has been a marked increase in the number of drugs available for the management of open-angle glaucoma. The development of these newer ophthalmic drugs has been prompted by a desire to make available, to the public, products that display maximum efficacy (with respect to the glaucoma) but minimal side effects on the body generally or on the health of the eye or on vision. The major development has been in a set of drugs active on {B-adrenergic receptors (the B-blockers"). While many of these newer drugs are, as yet, available only in Europe or Japan, in 1986, three new ophthalmic B-blockers became available in the English-speaking world. It is our intent in this article to review why there has been this major expansion in the number of drugs available to manage glaucoma or ocular hypertension...
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.003 | 0.003 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.002 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".