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Record W3208129759 · doi:10.1038/s41575-021-00523-4

Advancing the global public health agenda for NAFLD: a consensus statement

2021· review· en· W3208129759 on OpenAlexaff
Jeffrey V. Lazarus, Henry E. Mark, Quentin M. Anstee, Juan Pablo Arab, Rachel L. Batterham, Laurent Castéra, Helena Cortez‐Pinto, Javier Crespo, Kenneth Cusi, M. Ashworth Dirac, Sven Francque, Jacob George, Hannes Hagström, Terry T.‐K. Huang, Mona Ismail, Achim Kautz, Shiv Kumar Sarin, Rohit Loomba, Veronica Miller, Philip N. Newsome, Michael Ninburg, Ponsiano Ocama, Vlad Ratziu, Mary E. Rinella, Diana Romero, Manuel Romero‐Gómez, Jörn M. Schattenberg, Emmanuel Tsochatzis, Luca Valenti, Vincent Wai‐Sun Wong, Yusuf Yılmaz, Zobair M. Younossi, Shira Zelber‐Sagi, Fredrik Åberg, Leon A. Adams, Maryam Salem Al Khatry, Khalid Al Naamani, Omar Alfaro Murillo, Alina M. Allen, Faisal Abdullatif Alnaser, Saleh A. Alqahtani, Khalid Alswat, Domenico Alvaro, Raúl J. Andrade, Marco Arrese, Yaw Asante Awuku, Motala Ayesha, Oidov Baatarkhuu, Shokhista Bakieva, Rita Basu, Ramón Bataller, Shahinaz Bedri, Emanuele Bosi, Marc Bourlière, Radan Brůha, Elisabetta Bugianesi, Patrizia Burra, Marı́a Buti, Christopher D. Byrne, José Luís Calleja, Patrizia Carrieri, Flloyd Carter, Marlén Ivón Castellanos Fernández, Gabriela Castillo-Lopez, Graciela Castro‐Narro, Henry Lik‐Yuen Chan, Wah‐Kheong Chan, Yoosoo Chang, Massimo Colombo, Kirsten J. Coppell, Kathleen E. Corey, Antonio Craxı̀, Donna R. Cryer, Anuradha Supun Dassanayake, Antonieta de Ascenção Soares Martins, Victor de Lédinghen, Stefano DelPrato, Sandro Demaio, Hailemichael Desalegn, John Dillon, Ajay Duseja, Mattias Ekstedt, Mohamed El‐Kassas, Osama Mohamed Elsanousi, Gamal Esmat, Jian‐Gao Fan, Nathalie J. Farpour‐Lambert, Robert Flisiak, Yasser Fouad, Michael Fuchs, Rino Alvani Gani, Lynn H. Gerber, Hasmik Ghazinyan, Liana Gheorghe, George Boon‐Bee Goh, Henning Grønbæk, Aghayeva Gulnara, Saeed Hamid, Vanessa Hebditch, Ingrid J. Hickman, Samantha Hocking, Béla Hunyady, Ramazan Idılman, Isakov Va, Mohammad H. Jamal, Peter Jepsen, Natacha Jreige Iskandar, Myeong Jun Song, K. C. Sudhamshu, Satoru Kakizaki, George Kalamitsis, Fasiha Kanwal, Jia‐Horng Kao, Lee M. Kaplan, Takumi Kawaguchi, Yousef Khader, Seung Up Kim, Nicolas Kodjoh, Ger H. Koek, Kazuhiko Koike, Narcisse Komas, Marko Korenjak, Marcelo Kugelmas, Asma Labidi, Naomi F. Lange, Joel E. Lavine, Mariana Lazo, Nancy Y. Lee, Cosmas Rinaldi Adithya Lesmana, Chun‐Jen Liu, Michelle T. Long, Patricio López‐Jaramillo, Reza Malekzadeh, Mamun Al Mahtab, Giulio Marchesini, Rui Tato Marinho, S Vázquez, Lyudmila Mateva, Charles Mbendi Nlombi, P. Mélin, Ivana Mikolašević, Carla Musso, Atsushi Nakajima, Edna Nava, Alexander Nersesov, Dafina Nikolova, Suzanne Norris, Katja Novak, Jude A. Oben, Janus P. Ong, Charles Onyekwere, George Papatheodoridis, Imran Paruk, Keyur Patel, Maria Paula Macedo, Carlos Penha‐Gonçalves, Marlene Pérez Figueroa, Wolf Peter Hofmann, Salvatore Petta, Cláudia P. Oliveira, Puneet Puri, Calvin Q. Pan, Marek Rác, Johanna Ralston, Alnoor Ramji, Homie Razavi, Mário Reis Álvares‐da‐Silva, Stuart K. Roberts, Michael Roden, Tamsin Rose, Samir Rouabhia, Patrizia Rovere–Querini, Ian Rowe, Shakhlo Sadirova, Riina Salupere, Tobokalova Saparbu, Raymond Sayegh, Giada Sebastiani, Yosuke Seki, Josefina Selmo, Abdel Karim Sermé, Jonathan E. Shaw, Nick Sheron, Oren Shibolet, Marcelo Silva, Ігор Миколайович Скрипник, Piotr Socha, Joan B. Soriano, C Wendy Spearman, Kannan Sridharan, Juan José Suárez, Dhastagir Sultan Sheriff, Ki‐Chul Sung, Mark G. Swain, Frank Tacke, Shahrad Taheri, Soek-Siam Tan, Elliot B. Tapper, Hannele Yki‐Järvinen, Maja Thiele, Isaac Thom Shawa, Ieva Tolmane, Esther A. Torres, Michael Trauner, Sombat Treeprasertsuk, Adela Turcanu, Jonas Valantinas, Mette Vesterhus, Imam Waked, Sarah H. Wild, José Willemse, Robert J. Wong, Stavra A. Xanthakos, Dan Yock Young, Ming‐Lung Yu, Kenneth I. Zheng, Mudjat Zeybel, Ming‐Hua Zheng

Bibliographic record

VenueNature Reviews Gastroenterology & Hepatology · 2021
Typereview
Languageen
FieldMedicine
TopicLiver Disease Diagnosis and Treatment
Canadian institutionsUniversity of CalgaryMcGill University Health CentreUniversity of British ColumbiaUniversity Health Network
FundersJanssen PharmaceuticalsSanofi-Aventis DeutschlandNovartis PharmaGenentechJulius ClinicalEuropean Association for the Study of the LiverNovo Nordisk FondenShionogiAstellas PharmaNovo NordiskArrowhead PharmaceuticalsCoherus BiosciencesIntercept PharmaceuticalsTakeda Pharmaceuticals InternationalGalectoRosetrees TrustRegeneron PharmaceuticalsEuropean Federation of Pharmaceutical Industries and AssociationsMedpaceCelgeneAlexion PharmaceuticalsServierGilead SciencesCity University of New YorkAlnylam PharmaceuticalsSanofiGlaxoSmithKlineBristol-Myers SquibbEli Lilly and CompanyAllerganAstraZenecaAmgenNGM BiopharmaceuticalsPfizerNational Institute for Health and Care ResearchMedicines CompanyFalk Foundation
KeywordsMedicineStatement (logic)Public healthGlobal healthConsensus conferenceMEDLINEMission statementPublic relationsPolitical scienceNursingInternal medicineLaw

Abstract

fetched live from OpenAlex

Non-alcoholic fatty liver disease (NAFLD) is a potentially serious liver disease that affects approximately one-quarter of the global adult population, causing a substantial burden of ill health with wide-ranging social and economic implications. It is a multisystem disease and is considered the hepatic component of metabolic syndrome. Unlike other highly prevalent conditions, NAFLD has received little attention from the global public health community. Health system and public health responses to NAFLD have been weak and fragmented, and, despite its pervasiveness, NAFLD is largely unknown outside hepatology and gastroenterology. There is only a nascent global public health movement addressing NAFLD, and the disease is absent from nearly all national and international strategies and policies for non-communicable diseases, including obesity. In this global Delphi study, a multidisciplinary group of experts developed consensus statements and recommendations, which a larger group of collaborators reviewed over three rounds until consensus was achieved. The resulting consensus statements and recommendations address a broad range of topics — from epidemiology, awareness, care and treatment to public health policies and leadership — that have general relevance for policy-makers, health-care practitioners, civil society groups, research institutions and affected populations. These recommendations should provide a strong foundation for a comprehensive public health response to NAFLD. Non-alcoholic fatty liver disease (NAFLD) is a potentially serious liver disease with a substantial burden worldwide. In this Consensus Statement, a global multidisciplinary group of experts develop consensus statements and recommendations addressing a broad range of topics on NAFLD to raise awareness and spur action.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.048
metaresearch head score (Gemma)0.040
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Review · Consensus signal: none
Teacher disagreement score0.048
Threshold uncertainty score0.253

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0480.040
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0030.004
Bibliometrics0.0050.004
Science and technology studies0.0020.002
Scholarly communication0.0060.011
Open science0.0040.006
Research integrity0.0130.018
Insufficient payload (model declined to judge)0.0060.004

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.088
GPT teacher head0.431
Teacher spread0.343 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations736
Published2021
Admission routes1
Has abstractyes

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