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Advancing the global public health agenda for NAFLD: a consensus statement

2021· review· en· 736 citations· W3208129759 on OpenAlex· 10.1038/s41575-021-00523-4

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian affiliationAn author listed a Canadian institution. This is the only route the usual frame has.

Full frame distilled prediction

Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

Candidate categories
Meta-epidemiology (narrow)
Consensus categories
none
Domain
Candidate signal: noneConsensus signal: none
Study design
Candidate signal: Not applicableConsensus signal: none
Genre
Candidate signal: ReviewConsensus signal: Review
Teacher disagreement score
0.828
Threshold uncertainty score
1.000
Validation status
machine_predicted_unvalidated · codex-gemma-dda1882f352a

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0020.001
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0070.003
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Opus teacher head0.088
GPT teacher head0.431
Teacher spread
0.343 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Abstract

Non-alcoholic fatty liver disease (NAFLD) is a potentially serious liver disease that affects approximately one-quarter of the global adult population, causing a substantial burden of ill health with wide-ranging social and economic implications. It is a multisystem disease and is considered the hepatic component of metabolic syndrome. Unlike other highly prevalent conditions, NAFLD has received little attention from the global public health community. Health system and public health responses to NAFLD have been weak and fragmented, and, despite its pervasiveness, NAFLD is largely unknown outside hepatology and gastroenterology. There is only a nascent global public health movement addressing NAFLD, and the disease is absent from nearly all national and international strategies and policies for non-communicable diseases, including obesity. In this global Delphi study, a multidisciplinary group of experts developed consensus statements and recommendations, which a larger group of collaborators reviewed over three rounds until consensus was achieved. The resulting consensus statements and recommendations address a broad range of topics - from epidemiology, awareness, care and treatment to public health policies and leadership - that have general relevance for policy-makers, health-care practitioners, civil society groups, research institutions and affected populations. These recommendations should provide a strong foundation for a comprehensive public health response to NAFLD.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

The record

Venue
Nature Reviews Gastroenterology & Hepatology
Topic
Liver Disease Diagnosis and Treatment
Field
Medicine
Canadian institutions
University of CalgaryMcGill University Health CentreUniversity of British ColumbiaUniversity Health Network
Funders
Janssen PharmaceuticalsSanofi-Aventis DeutschlandNovartis PharmaGenentechJulius ClinicalEuropean Association for the Study of the LiverNovo Nordisk FondenShionogiAstellas PharmaNovo NordiskArrowhead PharmaceuticalsCoherus BiosciencesIntercept PharmaceuticalsTakeda Pharmaceuticals InternationalGalectoRosetrees TrustRegeneron PharmaceuticalsEuropean Federation of Pharmaceutical Industries and AssociationsMedpaceCelgeneAlexion PharmaceuticalsServierGilead SciencesCity University of New YorkAlnylam PharmaceuticalsSanofiGlaxoSmithKlineBristol-Myers SquibbEli Lilly and CompanyAllerganAstraZenecaAmgenNGM BiopharmaceuticalsPfizerNational Institute for Health and Care ResearchMedicines CompanyFalk Foundation
Keywords
MedicineStatement (logic)Public healthGlobal healthConsensus conferenceMEDLINEMission statementPublic relationsPolitical scienceNursingInternal medicineLaw
Has abstract in OpenAlex
yes