The unexplored potential of gas‐responsive polymers in drug delivery: progress, challenges and outlook
Why this work is in the frame
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Bibliographic record
Abstract
Abstract Targeted drug delivery based on polymeric nanoparticles has been a long‐standing interest in nanomedicine for its beneficial traits including controlled and localized drug release. Gas‐responsive polymers offer an advantageous platform and have been slowly gaining attention in spatially locating and displaying unique interactions of specific responsive chemical entities in polymeric chains with endogenous gaseous stimuli. In this review, we highlight recent developments in polymeric nanoformulations with stimulant chemical entities for gasotransmittors such as NO, CO, H 2 S, SO 2 , O 2 and CO 2 in enhancing efficacy in therapeutic interventions. We underline some challenges and limitations of exploring these systems for clinical applications, and how we can further tap into the potential of these emerging materials. © 2021 Society of Industrial Chemistry.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it