Interleukin-7Rα in the regulation of lymphoid anti-viral responses and homeostasis
Bibliographic record
Abstract
Interleukin-7 (IL-7) is a cytokine with well-established roles in lymphocyte development in the bone marrow and thymus. Recent discoveries have expanded IL-7’s contribution to enhancing the effector responses of CD8 T cells in chronic LCMV infection and tumor clearance. IL-7Rα is highly expressed by mature lymphocytes in the lungs, but how IL-7 directs their function in acute airway viral infections is unclear. Using multiple mouse models, I show in chapter 3 that loss of IL-7 signaling results in impaired production of IL-5 and IL-13 in lung group two innate lymphoid cells (ILC2s) following influenza infection. Conversely, mice treated with IL-7 have increased production of IL-5 and IL-13 by lung ILC2s. Moreover, I show that IL-7 regulates GATA3 and CD25 expression in lung and bone marrow ILC2s. However, IL-7 is non-essential for the expression of the anti-apoptotic protein Bcl-2 and survival of ILC2s. In chapter 4, I show that IL-7 signaling plays an important role in CD8 T cell responses to acute influenza infection. Specifically, IL-7Rα is required for a normal sized mediastinal lymph node and the expansion of influenza-specific CD8 T cells therein. Terminal differentiation of influenza-specific CD8 T cells requires normal IL-7 signaling as well. Interestingly, IL-7 also plays a selective role in enhancing the effector function of influenza-specific CD8 T cells depending on their antigen specificity. Finally, IL-7 is inducible in the lungs by multiple cellular sources following viral infection. These findings on IL-7 and its effects on lower respiratory diseases will be important for expanding the utility of therapeutics that are currently available.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".