Bibliographic record
Abstract
The zebrafish (Danio rerio) has become an excellent model organism for studying vertebrate development and disease. More than 1000 zebrafish mutants have been identified, where changes in specific genes have correlated with human defects. Many of these mutations occur in genes with orthologues in humans, leading to the creation of animal models that resemble human disease types. Examples of this are demonstrated by mutations seen in bone morphogenetic protein (BMP) family members in both humans and zebrafish. This project investigated whether mutations in the BMP growth differentiation factor 11 (GDF11) gene result in deficits during zebrafish neuron development. Neuronal development was characterized using in situ hybridization and immunofluorescence techniques. Changes in neuronal development were examined using probes recognizing neurons, including RMO44 and acetylated tubulin. Experimental results from this preliminary characterization contribute to the on-going characterization of phenotypes seen in GDF11 mutants. Discipline: Biology Faculty Mentor: Dr. Lisa Prichard
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".