Assessing the impact of select intestinal tract conditions on expression of lee encoded genes in enterohemorrhagic escherichia
Bibliographic record
Abstract
Enterohemorrhagic Escherichia coli (EHEC) O157:H7 strain 86-24 accomplishes successful infection upon creating attaching and effacing (A/E) lesions on the enterocytes found in the large intestine. The A/E lesion event is possible due to the type III secretion system (T3SS) spanning the EHEC inner and outer membrane. T3SS is a molecular syringe that enables EHEC to establish trans-kingdom interactions with human and other animal hosts. The assembly and regulation of the T3SS is poorly understood. GFP reporter assay experiments showed that short chain fatty acid (SCFA) mixes representative of the large intestine increase the activity of the esp promoter that precedes the espA gene, an important component of the T3SS. Attachment data experiments showed that EspA is essential for EHEC attachment to HEp-2 epithelial cells. The data shows that biochemical cues encountered by EHEC play a role in the regulation and assembly of the T3SS ultimately leading to A/E lesion formation.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".