Generalized Birnbaum–Saunders mixture cure frailty model: inferential method and an application to bone marrow transplant data
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Cluster time data are commonly encountered in survival analysis due to unobservable factors such as shared environmental conditions and genetic similarity. In such cases, careful attention needs to be paid to model the possible correlation between the subjects within the same cluster. Moreover, some diseases are curable due to great advances on modern medical techniques and treatments. For tracking these issues, we consider here a mixture cure frailty model, with generalized Birnbaum–Saunders frailty distribution, and propose a marginal likelihood approach for the estimation of model parameter. We approximate the intractable integrals in the likelihood function by the use of Monte-Carlo method. Thereafter, the maximum likelihood estimates are numerically determined. A simulation study and model discrimination are then carried out for evaluating the performance of the proposed model. It is observed from this study that the proposed model provides more flexibility and the method of inference is quite robust. Finally, we conduct an analysis of the effects of allogeneic and autologous bone marrow transplant treatments on acute lymphoblastic leukemia patients to demonstrate the usefulness of the proposed model and the method of inference.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it