P-193 Association between sleep-wake activity circadian rhythm and mild cognitive impairment among workers with pneumoconiosis in Hong Kong
Bibliographic record
Abstract
<h3>Introduction</h3> Weakened circadian activity rhythm was found to increase dementia and mild cognitive impairment (MCI) among female aged general population, but little is known among pneumoconiosis workers with male predominating. <h3>Objectives</h3> This study aims to investigate sleep-wake activity circadian rhythm of patients with pneumoconiosis and test the hypothesis that weakened circadian rhythm is associated with MCI. <h3>Methods</h3> We randomly enrolled patients with pneumoconiosis who participated in the annual interview activity. Community controls frequency-matched by age and sex were recruited as the reference. Participants wore wrist actigraphs continuously for 7 days (168 h) after completion of a standardized epidemiological questionnaire. Mesor, doubled amplitude acrophase and percent rhythm are the main circadian parameters and a higher value indicates a more robustness of circadian rhythm. MCI status was assessed using validated Chinese version of Montreal Cognitive Assessment (HK-MoCA) and Mini-mental state examination (MMSE) with a cutoff of 21/22 and 26/27, respectively. Co-variance analysis and multivariate logistic regression were performed to obtain adjusted mean of cognitive score and adjusted odds ratio (AOR). <h3>Results</h3> Workers with pneumoconiosis had significantly lower MoCA score than the community controls (20.5±0.4 vs. 22.0±0.5, p=0.03) after age and education were adjusted, while the difference in MMSE score was borderline (25.6±0.3 vs. 26.4±0.4, p=0.08). Mesor and Double amplitude were the circadian parameters that were notably lower among pneumoconiosis workers than the community controls. Compared with community controls with higher Mesor values, pneumoconiosis workers with lower Mesor levels had an AOR of 2.89 (95%CI: 1.20–6.95) for MCI measured by MoCA, which was relatively higher than that of the community controls (AOR=2.73, 95%CI: 0.94–7.93). Similar but attenuated results were observed for double amplitude. <h3>Conclusion</h3> This study provides the first epidemiological evidence that increased risks of mild cognitive impairment is associated with weakened circadian rhythm among pneumoconiosis workers.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".