P-193 Association between sleep-wake activity circadian rhythm and mild cognitive impairment among workers with pneumoconiosis in Hong Kong
Bibliographic record
Abstract
Introduction Weakened circadian activity rhythm was found to increase dementia and mild cognitive impairment (MCI) among female aged general population, but little is known among pneumoconiosis workers with male predominating. Objectives This study aims to investigate sleep-wake activity circadian rhythm of patients with pneumoconiosis and test the hypothesis that weakened circadian rhythm is associated with MCI. Methods We randomly enrolled patients with pneumoconiosis who participated in the annual interview activity. Community controls frequency-matched by age and sex were recruited as the reference. Participants wore wrist actigraphs continuously for 7 days (168 h) after completion of a standardized epidemiological questionnaire. Mesor, doubled amplitude acrophase and percent rhythm are the main circadian parameters and a higher value indicates a more robustness of circadian rhythm. MCI status was assessed using validated Chinese version of Montreal Cognitive Assessment (HK-MoCA) and Mini-mental state examination (MMSE) with a cutoff of 21/22 and 26/27, respectively. Co-variance analysis and multivariate logistic regression were performed to obtain adjusted mean of cognitive score and adjusted odds ratio (AOR). Results Workers with pneumoconiosis had significantly lower MoCA score than the community controls (20.5±0.4 vs. 22.0±0.5, p=0.03) after age and education were adjusted, while the difference in MMSE score was borderline (25.6±0.3 vs. 26.4±0.4, p=0.08). Mesor and Double amplitude were the circadian parameters that were notably lower among pneumoconiosis workers than the community controls. Compared with community controls with higher Mesor values, pneumoconiosis workers with lower Mesor levels had an AOR of 2.89 (95%CI: 1.20–6.95) for MCI measured by MoCA, which was relatively higher than that of the community controls (AOR=2.73, 95%CI: 0.94–7.93). Similar but attenuated results were observed for double amplitude. Conclusion This study provides the first epidemiological evidence that increased risks of mild cognitive impairment is associated with weakened circadian rhythm among pneumoconiosis workers.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".