Characterization of ASF1 and GCN5 in the ciliated protozoan tetrahymena thermophila
Bibliographic record
Abstract
One method of regulating accessibility of DNA is chromatin remodelling via histone post-translational modifications (PTM). Adding an acetyl group to the lysine residues (K) on the core histone H3 is one of these chemical modifications. Acetylation of H3 on lysine 56 (H3K56ac) is an important histone alteration that is conserved among most if not all eukaryotes including humans. Several histone acetyl transferases (HAT) have been shown to be responsible for H3K56ac in different organisms including Gen5 and p300/CPB in human cells and Rtt109 in fungi including the yeast Saccharomyces cerevisiae. In addition the histone chaperone ASf1, is also required for these modifications in yeast and human cells. The ciliated protozoan Tetrahymena thermophila is an effective model organism for studying the function of histone PTMs in certain processes including meiosis and RNA interference. Here, I show that tGen5 has H3 acetylation activity and that tAsf1 binds Histone H3.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".