Shell-Sheddable/Core-Degradable ABA Triblock Copolymer Nanoassemblies: Synthesis via RAFT and Concurrent ATRP/RAFT Polymerization and Drug Delivery Application
Bibliographic record
Abstract
Exploration of effective approaches that allow for the synthesis of smart block copolymers and their nanoassemblies exhibiting enhanced drug release upon stimuli-responsive degradation is in huge demand for drug delivery and pharmaceutical science. Herein, we report a new approach utilizing a combination of ATRP and RAFT polymerization techniques through sequential RAFT and concurrent ATRP/RAFT polymerization in the presence of an iniferter bearing both disulfide and acetal linkages labeled with terminal bromine (the ATRP initiating moiety) and dithioester groups (the RAFT chain transfer moiety). The approach enables the synthesis of an ABA-type triblock copolymer with both disulfide and acetal linkages at only one block junction as well as disulfide pendants in a hydrophobic block. The flower-type nanoassemblies, formed through aqueous micellization, exhibit dual reduction/acid responses at core–corona interfaces, leading to the detachment of coronas, as well as reduction response in cores, causing the dissociation of cores. The dual reduction/acid-responsive accelerated and synergistic release profile of an encapsulated doxorubicin, combined with cytotoxicity and cellular uptake in vitro, suggests the great potential of our approach toward effective intracellular drug delivery.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".