O-57 Aluminum Dust Exposure and Risk of Neurodegenerative Diseases in a Cohort of Male Miners in Ontario, Canada
Bibliographic record
Abstract
<h3>Introduction</h3> McIntyre Powder (MP), a fine-sized aluminum and aluminum compound powder, was administered to Ontario miners from 1943 to 1979 as purported prophylaxis against silicosis. Aluminum has long been suspected of having a role in the development of neurological diseases. However, very few studies have examined the risk of neurological disease among miners with exposure to aluminum dust, and previous findings were inconclusive. <h3>Objectives</h3> We estimated associations between respirable aluminum exposure through MP and neurological disease in a retrospective cohort of mining workers from Ontario, Canada. Outcomes included Alzheimer’s disease, Alzheimer’s with other dementias, Parkinson’s disease, parkinsonism, and motor neuron disease. <h3>Methods</h3> The cohort was created by linking a database of mining workers’ work history to health care records. This analysis included 36,826 male miners potentially exposed to MP between 1943 and 1979, followed up for disease diagnosis between 1992 and 2018. Exposure was assessed using two approaches, self-reported and historical records. Neurological diseases were ascertained using physician billing and hospital discharge records. Poisson regression models were used to estimate associations between MP exposure and neurological outcomes using incidence rate ratios and 95% confidence intervals (RR, 95% CI). <h3>Results</h3> Exposure to self-reported MP was associated with an elevated incidence rate of Parkinson’s disease (RR 1.34, 95% CI: 1.14, 1.57). The rate of Parkinson’s disease appeared to increase with the duration of exposure assessed by historical records. Ever-exposure to MP was positively associated with an elevated rate of Alzheimer’s with other dementias (RR 1.12, 95% CI 1.06, 1.19), but not Alzheimer’s disease alone. <h3>Conclusion</h3> This study found that miners who were exposed to respirable aluminum, as McIntyre Powder, had elevated rates of Parkinson’s disease. The rate of Parkinson’s disease appeared to increase with the duration of exposure assessed by historical records.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".