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Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017

2019· article· en· 2,665 citations· W3211488171 on OpenAlex· 10.1001/jamaoncol.2019.2996

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Abstract

<h3>Importance</h3> Cancer and other noncommunicable diseases (NCDs) are now widely recognized as a threat to global development. The latest United Nations high-level meeting on NCDs reaffirmed this observation and also highlighted the slow progress in meeting the 2011 Political Declaration on the Prevention and Control of Noncommunicable Diseases and the third Sustainable Development Goal. Lack of situational analyses, priority setting, and budgeting have been identified as major obstacles in achieving these goals. All of these have in common that they require information on the local cancer epidemiology. The Global Burden of Disease (GBD) study is uniquely poised to provide these crucial data. <h3>Objective</h3> To describe cancer burden for 29 cancer groups in 195 countries from 1990 through 2017 to provide data needed for cancer control planning. <h3>Evidence Review</h3> We used the GBD study estimation methods to describe cancer incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life-years (DALYs). Results are presented at the national level as well as by Socio-demographic Index (SDI), a composite indicator of income, educational attainment, and total fertility rate. We also analyzed the influence of the epidemiological vs the demographic transition on cancer incidence. <h3>Findings</h3> In 2017, there were 24.5 million incident cancer cases worldwide (16.8 million without nonmelanoma skin cancer [NMSC]) and 9.6 million cancer deaths. The majority of cancer DALYs came from years of life lost (97%), and only 3% came from years lived with disability. The odds of developing cancer were the lowest in the low SDI quintile (1 in 7) and the highest in the high SDI quintile (1 in 2) for both sexes. In 2017, the most common incident cancers in men were NMSC (4.3 million incident cases); tracheal, bronchus, and lung (TBL) cancer (1.5 million incident cases); and prostate cancer (1.3 million incident cases). The most common causes of cancer deaths and DALYs for men were TBL cancer (1.3 million deaths and 28.4 million DALYs), liver cancer (572 000 deaths and 15.2 million DALYs), and stomach cancer (542 000 deaths and 12.2 million DALYs). For women in 2017, the most common incident cancers were NMSC (3.3 million incident cases), breast cancer (1.9 million incident cases), and colorectal cancer (819 000 incident cases). The leading causes of cancer deaths and DALYs for women were breast cancer (601 000 deaths and 17.4 million DALYs), TBL cancer (596 000 deaths and 12.6 million DALYs), and colorectal cancer (414 000 deaths and 8.3 million DALYs). <h3>Conclusions and Relevance</h3> The national epidemiological profiles of cancer burden in the GBD study show large heterogeneities, which are a reflection of different exposures to risk factors, economic settings, lifestyles, and access to care and screening. The GBD study can be used by policy makers and other stakeholders to develop and improve national and local cancer control in order to achieve the global targets and improve equity in cancer care.

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The record

Venue
JAMA Oncology
Topic
Global Cancer Incidence and Screening
Field
Medicine
Canadian institutions
McMaster UniversityUniversity of AlbertaUniversity of British ColumbiaUniversity of TorontoPublic Health Agency of CanadaOttawa HospitalUniversity of ManitobaImpactMcGill UniversityUniversity of Calgary
Funders
Division of Cancer Epidemiology and Genetics, National Cancer InstituteNational Cancer InstituteDipartimento di Medicina e Chirurgia, Università degli Studi di Milano-BicoccaInvasive Fungi Research Center, Mazandaran University of Medical SciencesDepartment of Medicine, Ottawa HospitalCenter for International HealthResearch Institute for Endocrine Sciences, Shahid Beheshti University of Medical SciencesCollege of Medicine and Health Sciences, United Arab Emirates UniversityGastrointestinal and Liver Diseases Research CenterDrug Applied Research Center, Tabriz University of Medical SciencesMedical Research CouncilĐại học Quốc gia Hà NộiSchool of Public Health and Family Medicine, University of Cape TownComprehensive Cancer Center, University of Alabama at BirminghamInjury Prevention Research CenterWolkite UniversityDirectorate for Biological SciencesDebre Markos UniversityDamietta UniversityUniversitair Ziekenhuis AntwerpenMoscow Institute of Physics and TechnologyImam Abdulrahman Bin Faisal UniversityShahroud University of Medical SciencesBabol University of Medical SciencesMenzies Institute for Medical ResearchKurdistan University Of Medical SciencesLorestan University of Medical SciencesKwame Nkrumah University of Science and TechnologyUniversitas HasanuddinSavitribai Phule Pune UniversityMcGill UniversityAlexandria UniversityMansoura UniversityUniversity of PeradeniyaXiamen UniversityUniversitas AirlanggaUniversidad Autónoma de SinaloaShahid Beheshti University of Medical SciencesUniversitatea de Medicină şi Farmacie "Carol Davila" BucureştiGolestan University of Medical SciencesWestern Sydney UniversityTartu ÜlikoolCollege of Science and Engineering, University of MinnesotaShiraz University of Medical SciencesFakultet Medicinskih Nauka, Univerziteta U KragujevcuUniversità degli Studi di MilanoPomorski Uniwersytet Medyczny W SzczecinieQatar FoundationUniversidade Federal de Minas GeraisUniversity of HailUniversidade do PortoVirginia Commonwealth UniversityUniversità di BolognaBaqiyatallah University of Medical SciencesShahrekord University of Medical SciencesChungnam National University HospitalUniversidad Nacional Autónoma de MéxicoUniversity of New South WalesKermanshah University of Medical SciencesBirjand University of Medical SciencesUniversity of South CarolinaPacific Institute for Research and EvaluationQazvin University of Medical SciencesGuilan University of Medical SciencesUniversitair Medisch Centrum GroningenUniversity of GondarUnited Arab Emirates UniversityInstituto De Saúde Pública, Universidade do PortoAhvaz Jundishapur University of Medical SciencesMazandaran University of Medical SciencesShahrekord UniversityMinistry of Health and Medical EducationHaramaya UniversityNational Center of Neurology and PsychiatryMashhad University of Medical SciencesTaipei Medical UniversityTanta UniversityWorld Health OrganizationUrmia UniversityBabol Noshirvani University of TechnologyHamadan University of Medical SciencesInstitute for Research in Fundamental SciencesInyuvesi Yakwazulu-NataliSemmelweis EgyetemUniversity College LondonUniversiti Kebangsaan MalaysiaHawassa UniversityKuwait UniversityTampereen YliopistoTabriz University of Medical SciencesSeoul National University HospitalTsinghua UniversityUniversity of Cape TownKhalifa University of Science, Technology and ResearchStudent Research Committee, Tabriz University of Medical SciencesLa Trobe UniversityFrankfurt University of Applied SciencesKashan University of Medical SciencesKarolinska InstitutetKerman University of Medical SciencesPublic Health Agency of CanadaMadda Walabu UniversityUniversidade Federal de Juiz de ForaInstitució Catalana de Recerca i Estudis AvançatsRafsanjan University of Medical SciencesUnited Nations Population FundBushehr University of Medical SciencesKyung Hee UniversityTarbiat Modares UniversityHacettepe ÜniversitesiU.S. Department of Veterans AffairsKosin UniversitySun Yat-sen UniversityYonsei UniversityRijksuniversiteit GroningenSharif University of TechnologyAdigrat UniversityMorgan State UniversityUniversitätsklinikum HeidelbergOttawa Hospital Research InstituteKing Saud UniversityAin Shams UniversityCochrane South AfricaUniversity of TorontoImperial College LondonPublic Health EnglandQueensland University of TechnologyCairo UniversityLaboratório Associado para a Química VerdeUniversity of Health Sciences LahoreOklahoma State UniversityFlinders UniversityMonash UniversityWuhan UniversityUniversity of WashingtonSouth African Medical Research CouncilUniversitas Negeri SemarangSydney Medical SchoolNewcastle UniversityUniversitat de ValènciaHelsingin YliopistoDelhi Technological UniversityUniwersytet Jagielloński Collegium MedicumShiraz UniversityKing's College LondonMcMaster UniversityUniversity of LeicesterSanjay Gandhi Postgraduate Institute of Medical SciencesKrishna Institute Of Medical Sciences Deemed To Be UniversityUniversität UlmUniversity of EmbuHealth Services Management Research CenterDilla UniversityMaragheh University of Medical SciencesMekelle UniversityNational Institutes of HealthBanaras Hindu UniversityWollega UniversityUniversity of TabrizAhmadu Bello UniversityBrigham and Women's HospitalArak University of Medical SciencesRede de Química e TecnologiaRadboud UniversiteitAksum UniversityIslamic Azad UniversityWest Virginia UniversityUniversity of Health and Allied SciencesA.T. Still UniversityChristian Medical College, VelloreCurtin University of TechnologyUniversidade Federal de Santa CatarinaAmirkabir University of TechnologyApplied Molecular Biosciences UnitIran University of Medical SciencesEkiti State UniversityBahir Dar UniversityNational Center for Child Health and DevelopmentSheffield Hallam UniversityUniversidade Federal do Rio Grande do SulArabian Gulf UniversitySeattle Children's Research InstituteDeakin UniversityPublic Health AgencyEli Lilly and CompanySyddansk UniversitetJimma UniversityHarvard UniversityPostgraduate Institute of Medical Education and Research, ChandigarhSveučilište u ZagrebuSeoul National UniversityTehran University of Medical Sciences and Health ServicesUniversity of Technology SydneyDivision of Cardiothoracic Surgery, University of Colorado School of Medicine, Anschutz Medical CampusUniversity of JiroftDurban University of TechnologyUniversity of Texas at AustinBournemouth UniversityTrường Đại học Nguyễn Tất ThànhChungnam National UniversityAddis Ababa UniversityBall State UniversitySamara UniversityJordan University of Science and TechnologyHamad Bin Khalifa UniversityUniversity of OklahomaWellcome TrustJohns Hopkins UniversityWestfälische Wilhelms-Universität MünsterSt. Jude Children's Research HospitalTrường Đại học Duy TânUniversidade de BrasíliaCase Western Reserve UniversityHamad Medical CorporationBirmingham City UniversitySchool of Medicine, Boston UniversityJackson State UniversityUniversity of TasmaniaAlborz University of Medical SciencesNorthwestern UniversityUniversity of West FloridaIsfahan University of Medical SciencesInstituto de Salud Carlos IIISan Diego State University
Keywords
MedicineCancerIncidence (geometry)Cancer incidenceYears of potential life lostDemographyGerontologyLife expectancyPopulationEnvironmental healthInternal medicine
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