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Record W3211646893 · doi:10.1016/j.xgen.2021.100033

CanDIG: Federated network across Canada for multi-omic and health data discovery and analysis

2021· article· en· W3211646893 on OpenAlexaffabout
Lewis Jonathan Dursi, Zoltán Bozóky, Richard de Borja, Haoyuan Li, David Bujold, Adam Lipski, Shaikh Farhan Rashid, Amanjeev Sethi, Neelam Memon, Dashaylan Naidoo, Felipe Coral-Sasso, Matthew L. Wong, P-O Quirion, Zhibin Lu, Samarth Agarwal, Yuriy V. Pavlov, Andrew Ponomarev, Mia Husić, Krista Pace, Samantha Palmer, Stephanie A. Grover, Sevan Hakgor, Lillian L. Siu, David Malkin, Carl Virtanen, Trevor J. Pugh, Pierre‐Étienne Jacques, Yann Joly, Steven J.M. Jones, Guillaume Bourque, Michael Brudno

Bibliographic record

VenueCell Genomics · 2021
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicBioinformatics and Genomic Networks
Canadian institutionsMcGill UniversitySickKids FoundationHospital for Sick ChildrenMcGill Genome CentreUniversity of WaterlooVector InstituteOntario GenomicsCanada's Michael Smith Genome Sciences CentreProvidence Health CareProvincial Health Services AuthorityUniversity of British ColumbiaZymeworks (Canada)Princess Margaret Cancer CentreInstitute of Cancer ResearchOntario Institute for Cancer ResearchUniversité de SherbrookeUniversity of TorontoUniversity Health Network
Fundersnot available
KeywordsGenomicsData scienceAllianceBig dataKey (lock)Computer scienceWorld Wide WebGenomeData miningBiologyGeographyComputer security

Abstract

fetched live from OpenAlex

We present the Canadian Distributed Infrastructure for Genomics (CanDIG) platform, which enables federated querying and analysis of human genomics and linked biomedical data. CanDIG leverages the standards and frameworks of the Global Alliance for Genomics and Health (GA4GH) and currently hosts data for five pan-Canadian projects. We describe CanDIG's key design decisions and features as a guide for other federated data systems.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.007
metaresearch head score (Gemma)0.013
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Methods · Consensus signal: Methods
Teacher disagreement score0.970
Threshold uncertainty score0.216

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0070.013
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0050.010
Science and technology studies0.0050.002
Scholarly communication0.0060.004
Open science0.0050.008
Research integrity0.0010.002
Insufficient payload (model declined to judge)0.0140.005

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.029
GPT teacher head0.280
Teacher spread0.252 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreMethods

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations27
Published2021
Admission routes2
Has abstractyes

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