MétaCan
Menu
Back to cohort
Record W3212315066 · doi:10.21105/joss.03756

A flexible search system for high-accuracy identification of biological entities and molecules

2021· article· en· W3212315066 on OpenAlex
Max Franz, Jeffrey V. Wong, Metin Can Siper, Christian Dallago, John Giorgi, Emek Demir, Chris Sander, Gary D. Bader

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueThe Journal of Open Source Software · 2021
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenetics, Bioinformatics, and Biomedical Research
Canadian institutionsPrincess Margaret Cancer CentreLunenfeld-Tanenbaum Research InstituteUniversity Health NetworkMount Sinai HospitalUniversity of Toronto
FundersNational Institutes of Health
KeywordsIdentification (biology)Computer scienceComputational biologyBiologyEcology

Abstract

fetched live from OpenAlex

Identifying subcellular biological entities (genes, gene products, and small molecules) is essential in using and creating bioinformatics analysis tools, text mining, and accessible biological research apps. When research information is uniquely and unambiguously identified, it enables data to be accurately retrieved, cross-referenced, and integrated. In practice, biological entities are identified when they are associated with a matching record from a knowledge base that specialises in collecting and organising information of that type (e.g. genes in NCBI Gene). Our search service increases the efficiency and ease of use for identifying biological entities compared to prior approaches (

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.102
Threshold uncertainty score0.210

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.041
GPT teacher head0.327
Teacher spread0.286 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it