Long-term Outcomes of Fixed-Combination Halobetasol Propionate and Tazarotene Lotion Stratified by Baseline Signs and Symptoms of Psoriasis
Bibliographic record
Abstract
OBJECTIVE • In this post hoc analysis of a 52-week open-label study (NCT02462083), 1 we assessed the efficacy and safety of once-daily halobetasol propionate (0.01%) and tazarotene (0.045%) lotion (HP/TAZ) in 550 participants with psoriasis stratified by baseline signs and symptoms of disease CONCLUSIONS • Long-term use of HP/TAZ was generally associated with treatment success regardless of baseline symptom severity, and no new safety signals emerged over 52 weeks • Participants with mild baseline symptoms were less likely to experience local skin reactions postbaseline compared with participants with more severe baseline symptoms • Evaluation of patients' baseline itch, dryness, and stinging/burning may help predict outcomes of HP/TAZ treatment • Clinicians can use this information to counsel patients regarding treatment expectations when initiating HP/TAZ
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.002 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".