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Record W3212523793 · doi:10.1016/j.jaci.2021.10.030

TNF inhibition in vasculitis management in adenosine deaminase 2 deficiency (DADA2)

2021· article· en· W3212523793 on OpenAlexaff
Natalie Deuitch, Dan Yang, Pui Y. Lee, Xiaomin Yu, Natalia Sampaio Moura, Oskar Schnappauf, Amanda K. Ombrello, Deborah L. Stone, Hye Sun Kuehn, Sergio D. Rosenzweig, Patrycja Hoffmann, Cornelia Cudrici, Deborah M. Levy, Elizabeth R. Kessler, Jennifer B. Soep, Arielle D. Hay, Austin Dalrymple, Yu Zhang, Li Sun, Qiuye Zhang, Xuemei Tang, Yuan Wu, Koneti Rao, Haibo Li, Hong Luo, Yao Zhang, Jon M. Burnham, Manfred Boehm, Karyl S. Barron, Daniel L. Kastner, Ivona Aksentijevich, Qing Zhou

Bibliographic record

VenueJournal of Allergy and Clinical Immunology · 2021
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicAdenosine and Purinergic Signaling
Canadian institutionsSickKids FoundationHospital for Sick ChildrenUniversity of Toronto
FundersNatural Science Foundation of Zhejiang ProvinceNational Key Research and Development Program of China Stem Cell and Translational ResearchNational Human Genome Research InstituteNational Key Research and Development Program of ChinaFoundation for Innovative Research Groups of the National Natural Science Foundation of ChinaNational Natural Science Foundation of China
KeywordsProinflammatory cytokineImmunologyAdenosine deaminase deficiencyInflammationMedicineTumor necrosis factor alphaCytokineAdenosine deaminaseAdenosineInternal medicine

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.672
Threshold uncertainty score0.352

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.014
GPT teacher head0.288
Teacher spread0.274 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations53
Published2021
Admission routes1
Has abstractno

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