Virtual Chip-Seq Predictions Of Binding Of 36 Transcription Factor In Roadmap Epigenomics Project Tissues
Bibliographic record
Abstract
This dataset contains predictions of Virtual ChIP-seq for binding of 36 transcription factors in Roadmap Epigenomics dataset tissues with matched DNase-seq and RNA-seq data. Tarball contains subfolders for each of the 36 TFs where Virtual ChIP-seq median MCC in validation cell types was > 0.3. Each subfolder contains gzipped BED files. Each file is named as _ _ _ _Predictions.bed.gz. Columns correspond to Chromosome, Start, End, _ _ _ , Posterior probability You can use the posterior probabilities provided in Virchip_PosteriorCutoffs_V3.0.0.tsv. These are posterior probability cutoffs which maximized MCC in H1-hESC cell type, or are set to 0.4 if there was no ChIP-seq data of that TF in H1-hESC (0.4 is the mode of all optimal posterior probability cutoffs in H1-hESC).
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.002 |
| Bibliometrics | 0.001 | 0.002 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.002 | 0.002 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.033 | 0.034 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".