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Record W3214448005 · doi:10.1016/j.xcrm.2021.100454

Pancreatic islets in bed with microvasculature—companions for life

2021· letter· en· W3214448005 on OpenAlexafffund
Corinne A. Hoesli, Timothy J. Kieffer

Bibliographic record

VenueCell Reports Medicine · 2021
Typeletter
Languageen
FieldMedicine
TopicPancreatic function and diabetes
Canadian institutionsUniversity of British ColumbiaMcGill University
FundersNational Institutes of HealthCanada Research ChairsCanadian Institutes of Health ResearchGenome British ColumbiaJuvenile Diabetes Research Foundation Canada
KeywordsProgenitor cellPancreatic isletsEmbryonic stem cellStem cellStreptozotocinMicrovesselIsletCellTransplantationInternal medicineMedicineDiabetes mellitusEndocrinologyBiologyCell biologyAngiogenesisGenetics

Abstract

fetched live from OpenAlex

In Cell Stem Cell, Aghazadeh et al.1Aghazadeh Y. Poon F. Sarangi F. Wong F.T.M. Khan S.T. Sun X. Hatkar R. Cox B.J. Nunes S.S. Nostro M.C. Microvessels support engraftment and functionality of human islets and hESC-derived pancreatic progenitors in diabetes models.Cell Stem Cell. 2021; (S1934-5909(21)00338-6)https://doi.org/10.1016/j.stem.2021.08.001Abstract Full Text Full Text PDF PubMed Scopus (19) Google Scholar show that human embryonic stem cell-derived pancreatic progenitors can reverse hyperglycemia for several weeks in streptozotocin-induced diabetic mice when co-transplanted with microvessel fragments into the subcutaneous space.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow), Insufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Commentary · Consensus signal: Commentary
Teacher disagreement score0.074
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0020.000
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0010.002
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.019
GPT teacher head0.243
Teacher spread0.224 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designNot applicable
Domainnot available
GenreCommentary

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations6
Published2021
Admission routes2
Has abstractyes

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