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Record W3215684008 · doi:10.21203/rs.3.rs-963149/v1

Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease

2021· preprint· en· W3215684008 on OpenAlexaff
Stéphanie Debette, Marie‐Gabrielle Duperron, Maria J. Knol, Quentin Le Grand, Tavia E. Evans, Aniket Mishra, Gennady V. Roshchupkin, Takahiro Konuma, David‐Alexandre Trégouët, José R. Romero, Stefan Frenzel, Michelle Luciano, Edith Hofer, Mathieu Bourgey, Nicole Dueker, Pilar Delgado, Saima Hilal, Rick M. Tankard, Florian Dubost, Jean Shin, Yasaman Saba, Nicola Armstrong, Constance Bordes, Mark E. Bastin, Alexa Beiser, Henry Brodaty, Robin Bülow, Caty Carrera, Christopher Chen, Ching‐Yu Cheng, Ian J. Deary, Piyush Gampawar, Jayandra J. Himali, Jiyang Jiang, Shuo Li, Mélissa Macalli, Pascale Marquis, Zoë Morris, Susana Muñoz Maniega, Matthew Paradise, Parva Pedram, Tatjana Rundek, Muralidharan Sargurupremraj, Sabrina Schilling, Omar Soukarieh, Alexander Teumer, Anbupalam Thalamuthu, Julian N. Trollor, Ami Tsuchida, María Valdés Hernández, Meike W. Vernooij, Uwe Völker, Katharina Wittfeld, Tien Yin Wong, Margaret J. Wright, Qiong Yang, Junyi Zhang, Wanting Zhao, Ycheng Zhu, Helena Schmidt, Perminder S. Sachdev, Wei Wen, Anne Joutel, Claudia L. Satizábal, Ralph L. Sacco, Guillaume Bourque, Mark Lathrop, Tomáš Paus, Israel Fernández‐Cadenas, Bernard Mazoyer, Yukinori Okada, Hans J. Grabe, Karen A. Mather, Reinhold Schmidt, M. Arfan Ikram, Christophe Tzourio, Joanna M. Wardlaw, Sudha Seshadri, Hieab H.H. Adams

Bibliographic record

VenueResearch Square · 2021
Typepreprint
Languageen
FieldMedicine
TopicIntracerebral and Subarachnoid Hemorrhage Research
Canadian institutionsUniversité de MontréalSickKids FoundationUniversity of TorontoMcGill UniversityHospital for Sick ChildrenMcGill Genome Centre
FundersAgence Nationale de la Recherche
KeywordsPerivascular spaceSpace (punctuation)DiseaseNeuroscienceMedicineBusinessPathologyComputer scienceBiology

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.003
Threshold uncertainty score0.008

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0010.001
Open science0.0000.000
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0030.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.051
GPT teacher head0.340
Teacher spread0.289 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations3
Published2021
Admission routes1
Has abstractno

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