Evaluation of a Novel Zonular Tension Restoring Accommodating Silicone IOL Design: Pilocarpine and Cyclopentolate-Induced Effect 20 Months after Implantation
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Bibliographic record
Abstract
Purpose . To investigate a novel zonular‐stress restoring accommodating 1‐piece silicone IOL. Setting . Angeles City, Philippines. Design . Prospective randomized bilateral study. Methods . Each patient received a study IOL (ActaLens™, Emmetrope, La Canada, CA) in one eye and a control IOL (CrystaLens® AO, B&L, USA, or an AcrySof IQ®, Alcon, USA) in the contralateral eye to allow for intraindividual comparison. At the 20‐month follow‐up, two measurement days were set to measure all eyes before and after instilling 2% pilocarpine on the first day and 1% cyclopentolate on the second measurement day using an optical biometry device (Lenstar, Haag‐Streit AG, Switzerland), respectively. PCO was graded by two examiners independently at the slit lamp. Results . In total, 16 eyes of 8 patients were included. In the study group and the control group, the pilocarpine‐induced ACD shift was 0.32 mm (SD: 0.12) ( p = 0.014) and 0.04 mm (SD: 0.16) ( p = 0.854), respectively. In the study group and the control group, the mean cyclopentolate‐induced ACD shift was 0.14 (SD: 0.06) ( p = 0.014) and 0.03 mm (SD: 0.03) ( p = 0.181), respectively. PCO and Nd : YAG rates were higher in the study group, but differences were not found to be significant (AcrySof vs. ActaLens p = 0.100 and CrystaLens vs. ActaLens p = 0.174). Conclusion . The investigated IOL is a novel concept for an accommodating IOL, and results showed a moderate pilocarpine‐induced forward shift of the IOL 20 months following implantation. For all patients, the investigated IOL seems to have a higher PCO rate compared to standard monofocal IOLs.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it