Bibliographic record
Abstract
Alkaline phosphatases are enzymes responsible for dephosphorylation of phosphate monoesters. They are involved in numerous biological processes but play a particularly important role in bone development and liver function. Abnormal levels of these enzymes can have detrimental effects on the corresponding processes. This study involved enzyme kinetic studies on bovine alkaline phosphatase to test the effects of substrate and enzyme concentrations, pH, and the addition of known and novel inhibitors. Increased substrate and enzyme concentrations increased the rate of catalysis and allowed for the determination of kinetic constants; Km and Vmax. The optimal pH was determining to be approx. 10, and from comparison of rates of catalysis between uninhibited and inhibited assays, the mode of inhibition was determined to be competitive for the known inhibitors: EDTA and phosphate. Several novel thiazole-based inhibitors with different substitution patterns were also synthesized and tested for their efficacy. Department: Biology Faculty Mentor: Dr. Tina Bott
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.006 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.002 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".