Effect of anti-migraine 5-HTBDF receptor agonists on In Vivo serotonin synthesis rates in rat and human brain
Bibliographic record
Abstract
Purpose. This work investigates the effect of anti-migraine serotonin (5-HT) receptor agonists (the triptans) on in vivo 5-HT synthesis rates in the brain. In rats, rates are examined after acute and chronic drug administration. In humans, rates are measured in different migrainous conditions, namely, during a headache, after sumatriptan, and between attacks. Methods. Synthesis rates are determined using the alpha-[14C or 11C]methyl- L-tryptophan tracer kinetic model, combined in rats with autoradiography and in humans with positron emission tomography. Results & conclusions . Acute triptan administration reduces 5-HT synthesis rates in rat brain while chronic delivery increases rates at serotonergic projection areas. Preliminary results in human migraine sufferers suggest a trend, though not significant, towards an acute decrease in central rates after sumatriptan injection and higher rates during migraine pain than between attacks. Such central effects might or might not help alleviate pain but would have repercussions for chronic triptan users.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".