Impact of image pre-processing methods on computed tomography radiomics features in chronic obstructive pulmonary disease
Bibliographic record
Abstract
Abstract Computed tomography (CT) imaging texture-based radiomics analysis can be used to assess chronic obstructive pulmonary disease (COPD). However, different image pre-processing methods are commonly used, and how these different methods impact radiomics features and lung disease assessment, is unknown. The purpose of this study was to develop an image pre-processing pipeline to investigate how various pre-processing combinations impact radiomics features and their use for COPD assessment. Spirometry and CT images were obtained from the multi-centered Canadian Cohort of Obstructive Lung Disease study. Participants were divided based on assessment site and were further dichotomized as No COPD or COPD within their participant groups. An image pre-processing pipeline was developed, calculating 32 grey level co-occurrence matrix radiomics features. The pipeline included lung segmentation, airway segmentation or no segmentation, image resampling or no resampling, and either no pre-processing, binning, edgmentation, or thresholding pre-processing techniques. A three-way analysis of variance was used for method comparison. A nested 10-fold cross validation using logistic regression and multiple linear regression models were constructed to classify COPD and assess correlation with lung function, respectively. Logistic regression performance was evaluated using the area under the receiver operating characteristic curve (AUC). A total of 1210 participants (Sites 1–8: No COPD: n = 447, COPD: n = 413; and Site 9: No COPD: n = 155, COPD: n = 195) were evaluated. Between the two participant groups, at least 16/32 features were different between airway segmentation/no segmentation ( P ≤ 0.04), at least 29/32 features were different between no resampling/resampling ( P ≤ 0.04), and 32/32 features were different between the pre-processing techniques ( P < 0.0001). Features generated using the resampling/edgmentation and resampling/thresholding pre-processing combinations, regardless of airway segmentation, performed the best in COPD classification (AUC ≥ 0.718), and explained the most variance with lung function ( R 2 ≥ 0.353). Therefore, the image pre-processing methods completed prior to CT radiomics feature extraction significantly impacted extracted features and their ability to assess COPD.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.005 | 0.014 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.002 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".