Reaksi dekuarternerisasi garam 2-Siano-N,N,N-trimetil Etanamonium Ionida
Bibliographic record
Abstract
Transformasi amina tersier dilakukan untuk memperoleh senyawa turunannya yang lebih potensial. Salah satu tahap penting dalam transfonnasinya adalah dekuarternerisasi spesifik garam amonium yang disintesis dari alkilasi terhadap amina primer atau sekunder. Sintesis garam amonium alifatik 2-siano-N,N,N-trimetil etanamonium iodida (tahap 1) dan reaksi dekuarternerisasinya dengan trifenilpospin (tahap II) telah dilakukan. Pembentukan garam amonium dilakukan dengan mengadisi akrilonitril (CH2-.--CHCN) dengan dimetil amin ((CH3)2NH), meinberikan rendemen dimetilamino propionitril sebesar 62 %, diikuti metilasi terhadap amina tersebut menghasilkan rendemen garam 2-siano-N,N,N-trimetil etanamonium iodida sebesar 72 %. Reaksi garam ini dengan trifenilpospin dalam pelarut polar aprotik asetonitril pada suhu 82 °C selama 18 jam. Peranan nukleofil ekstemal tidak terlalu selektif, hanya menghasilkan 71 % produk demetilasi dan produk lainnya 24 % campuran produk desianoetilasi dan 13-eliminasi. Analisa produk dilakukan dengan GC, GC-MS dan Spektroskopi Resonansi Magnetik Inti 1H-NMR Tertiary amine transformation was done to get its potential derivates. One of its important step of transformations is specific dequaternarisation of ammonium salt synthesized by alkylations of primary or secondary amine. Synthesis of aliphatic ammonium salt, 2-cyano-N,N,N-trimethyl etanammonium iodide (step I), and it's dequarternerysation in the presence of triphenylphosphine (PPh3) (step II) has been done. The formation of ammonium salt has been realized by addition of dimethylamine to acrylonitrile gave 62 % of dimethylamino propionitrile ((CH3)2NCH2CH2CN) followed direct methylation of this amine gave 72 % of 2-cyano-N,N,N-trimethyl etanammonium iodide salt. Reaction of this ammonium salt with triphenylphosphine was carried out in polar aprotic solvent acetonitrile at 82 °C during 18 hours. In this case, aplication of external nucleophile is not selective, only 71% of dimethylation product and 24 % of decyanoethylation and 0-elimination product. Product has been analized by GC, GC-MS and Spectroscopy 11-1-NMR
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.009 | 0.003 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".