Male Coho Salmon (Oncorhynchus kisutch) Exposed to a Time-Course of Urban Sewage Effluent Exhibit a Sporadic Low Incidence of Sex Reversal and Intersex
Bibliographic record
Abstract
Abstract Developing coho salmon alevin (Oncorhynchus kisutch) were exposed to concentrations of 1 to 10% municipal wastewater effluent (MWWE) during the labile period of sexual differentiation. MWWE was collected at regular time intervals from a municipal wastewater treatment plant during a 4-week period that coincided with the latter part of the spawning season of coho salmon. The salmon were exposed, from just prior to hatch until 28 d post hatch, to MWWE collected at 3 a.m., 8 a.m., 3 p.m. or 8 p.m. Subsequent gonadal development was assessed by histology and compared to genetic sex as determined by Y-chromosomal DNA markers. The MWWE (analyzed using GC-HRMS) had relatively high concentrations of steroidal estrogens and other endocrine active substances at some time points during the exposure period. A low incidence of intersex and sex reversal was noted in the coho salmon exposed to MWWE collected at only two time points; 3 a.m. (1% MWWE) and 8 p.m. (10% MWWE), and ≤19% of the male fish in these exposure groups were affected. The coho salmon utilized were of wild genetic backgrounds and thus the sporadic nature of the response observed may be due to a significant genetic influence on the ability to respond to exogenous hormones at this early stage of development.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".