Гендерные различия в реакциях на воздействие земной и космической погоды на гемодинамику больных пожилого и старческого возраста с гипертонической болезнью III стадии, 3 степени на фоне терапии ингибиторами ангиотензинпревращающего фермента и блокаторами рецепторов ангиотензина II

It is a well-known fact that variations in atmospheric pressure and temperature, geomagnetic activity (magnetic storm), humidity could decrease hypotensive effect of therapy patients with arterial hypertension. At the same time, in Russia, population / gender research in this field are still little developed. aims of our work are (i) investigation of this problem by data of therapy in patients with hypertensive disease stage 3 by the angiotensin-converting-enzyme inhibitors (ACE inhibitors) and angiotensin receptors blockators (ARBs II) in gender aspects: (ii) estimation of efficacy these therapy against the background of meteorological and geomagnetic impacts. We carried out clinical study (during period from 2 Feb. 2011 till June 2012) and processing of the results on the basis of, correspondingly, Moscow City Clinical Hospital no. 60 and Institute of Cosmic Research of RAS. We obtained Earth and Cosmic Weather Data from websites ftp://ftp.ngda.gov/stp/eomagnetic-data-indices/kp-ap and http//meteo.infospace.ru, and processed received results by prediction method. In our clinical studies, we used such ACE inhibitors as prestarium, noliprel, and lozap, losartan lorista, blocktran as ARBs We registered hemodynamic parameters by daily monitors (Shiller AT-10) and by self-control of blood pressure during day and night from the 1st till 18th day and during 3 months ambulatory. We investigated correlation coefficients between the 1st and following days of hospitalization of each patient, and calculated delta between data before and after therapy. Method of variation statistics allow us to obtain the following results: (a) in hypertension stage 3, 3 degrees during treatment with BRAs II hypotensive response elderly women was greater than in older men; (b) there are gender differences in clinical symptoms with their significant improvement in elderly women under the influence of ACE inhibitors affected hypertension of 3 phase, 3 degrees; (c) we are first to found no gender differences in hemodynamics in hypertensive effect of ACE inhibitors in elderly patients with hypertensive disease stage 3, 3 degrees. We also revealed differences between elderly men and women with hypertensive disease stage III, grad 3 in diverse of parameters of atmospheric pressure humidity, temperature, and Kp-index on the background of therapy ACE inhibitors and ARBs Despite the fact that this study is only preliminary, we can conclude that there are significant gender differences in the course and treatment of hypertension. gender differences; angiotensin converting enzyme inhibitors; angiotensin receptor blockers II; the parameters of the Earth and Space Weather Carter C.S., Onder G., Kritchevsky S.B., Pahor M. Enzyme Inhibition Intervention in Elderly Persons: Effects on Body Composition and Physical Performance. Journals of Gerontology Series A: Biological Sciences and Medical Sciences 60.11 (2005): 1437–1446. Gogin E.E. Hypertensive Heart Disease: Pathogenesis, Diagnosis, And Treatment Options. Consilium Medicum. N.p., 1 May 2004. Web. . (In Russian). Gurfinkel Yu., Breus T., Zenchenko T., Ozheredov V. 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Tarlovskaya I.I., Suvorov D.A., Sobolev A.V. Gender Differences in Efficacy of Antihypertensive Therapy: Losartan and Enalapril. Consilium Medicum. N.p. 1 Feb. 2012. Web . (In Russian). Zaslavskaya R.M., Krivchikova L.V. Gender Differences of Treatment Effectiveness in Elderly and Senile Patients with Essential Hypertension and Ischemic Heart Disease with II Receptor and Converting Enzyme Inhibitors. Clinical Medicine 10 (2013): 67. (In Russian). Zenchenko T.A., Skavulyak A.N., Khorseva N.I., Breus T.K. Characteristics of the Individual Reactions of Healthy People Cardiovascular System to Change the Meteorological Factors in a Wide Range of Temperatures. Geophysical Processes and the Biosphere 12.1 (2013): 22–44. (In Russian). Zaslavskaya, R. M., L. V. Krivchikova, M. M. Teiblum, T. K. Breus, and V. A. Ozheredov. 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