Bibliographic record
Abstract
目的探讨中药克疣灵口服液对经6Gy γ-线照射后的SD大鼠及尖锐湿疣(CA)病人外周血清白细胞介素(IL-18)、肿瘤坏死因子(TNF)-α水平、自然杀伤细胞(NK)活性,以及对局部瘤体组织IL-18、TNF-α表达水平的调节作用机理.方法采用6Gy γ-线连续照射SD大鼠(0.6Gy/min,距60Coγ源0.1m,15min/次/日,15日)造成细胞免疫缺陷的实验动物病理模型,并灌饲高低剂量克疣灵口服液.临床研究设克疣灵口服液治疗组45例,病人,给予克疣灵口服液50ml,3次/日,口服;局部外用克疣灵外搽剂4次/日,共6周.对照组40例病人,肌注α-1b基因工程干扰素300万U/次,3次/周;外搽人重组α-2b干扰素凝胶4次,共6周.动物灌饲与病人疗程结束后,采用酶联免疫吸附试验(ELISA)双抗体夹心法测定外周血清IL-8、TNF-α水平,CA病人局部瘤体组织IL-18、TNF-α表达水平,采用同位素释放法测定动物脾脏NK细胞与人NK细胞活性.结果 克疣灵口服液能显著提高造模动物与CA病人外周血清IL-18、TNF-α水平,增强NK细胞的活性,疗后治疗组瘤体治疗部位IL-18、TNF-α表达水平显著高于对照组.结论 克疣灵口服液具有显著的正向免疫调节作用,能显著改善造模动物细胞免疫缺陷,增强CA病人的细胞免疫能力.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.006 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.041 | 0.007 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".