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Cord Blood Banking for Regenerative Therapy

2011· book-chapter· en· W36187950 on OpenAlexaff
Jennifer Ann Klowak, Yuan Chung, David Allan

Bibliographic record

VenueHumana Press eBooks · 2011
Typebook-chapter
Languageen
FieldMedicine
TopicMesenchymal stem cell research
Canadian institutionsUniversity of OttawaOttawa Hospital
Fundersnot available
KeywordsRegenerative medicineCord bloodMedicineInternal medicineBiologyStem cellCell biology

Abstract

fetched live from OpenAlex

The first successful umbilical cord blood (UCB) transplant in 1989 on a patient with Fanconi anemia sparked the creation of cord blood banks worldwide, including more than 100 public banks and nearly 500,000 banked units. Although cord blood units have been historically collected and stored for use in hematopoietic transplantation, there is increasing attention regarding nonhematopoietic cells within cord blood units and their important regenerative functions, making the prospect of using UCB for vascular repair or regenerative therapy most exciting. In this chapter, we provide an outline of various cell types with regenerative function that are present in UCB units and discuss the potential role of using banked cord blood cells for regenerative therapy. These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.022
Threshold uncertainty score0.072

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0010.001
Scholarly communication0.0020.002
Open science0.0010.001
Research integrity0.0010.002
Insufficient payload (model declined to judge)0.0220.011

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.311
GPT teacher head0.356
Teacher spread0.045 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2011
Admission routes1
Has abstractyes

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