Searching for crp: Investigating Candidate Genes for the cAMP Receptor Protein in Bdellovibrio bacteriovorus
Bibliographic record
Abstract
Bdellovibrio bacteriovorus is a δ-proteobacter with an obligatory predatory lifestyle, consuming a wide variety of Gram-negative bacteria. Its unusual life cycle and genome make it a particularly interesting organism to study. In this experiment, three candidate crp homologs – Bd0446, Bd2590, and Bd2602 – were evaluated by complementation studies in Escherichia coli, and characterized by bioinformatic analysis. Based on the complementation studies, none of these genes function as a crp homolog in E. coli. However, comparative bioinformatic analysis strongly suggests that either Bd2590 or Bd2602 may indeed code for the cyclic AMP receptor protein in Bdellovibrio, and merit further investigation. Additionally, a fourth homologue, Bd2591, was identified, and remains to be explored.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".