Food allergy and anaphylaxis – 2049. Evolution of food allergy in a high risk population: the Canadian asthma primary prevention study (CAPPS)
Bibliographic record
Abstract
This article was originally published online on 23 April 2013 Food allergy is on the rise. It is often assumed that allergy in early life to milk and egg often resolves whereas this is less frequent with peanut. CAPPS is a high risk allergy and asthma birth cohort. 545 families were enrolled during pregnancy in Winnipeg and Vancouver, Canada. Study participants were prenatally randomized into a multifaceted modified diet, lifestyle and environment intervention group or control group. Questionnaires were completed prenatally and when the children were assessed by a Pediatric Allergist at 1, 2, 7 and 15 years of age. Assessments included skin testing to common inhalant and ingestant (milk, egg and peanut) allergens. A positive skin test was defined as having a mean wheal diameter ≥ 3mm. At age 1, 3.4% (16/474) of children were sensitized to milk, 9.1% (43/474) to egg and 5.3% (25/474) to peanut. At age 15, 1.6% (5/321) were sensitized to milk, 1.9% (6/321) to egg and 10.9% (35/321) peanut. At age 15, 100% of children sensitized to milk and egg at age 1 were no longer sensitized to those foods. Interestingly 64% (16/25) of the children sensitized to peanut at age 1 outgrew sensitization to peanut at age 15. New food sensitizations developed between the ages of 1 and 15. Sensitization to peanut at age 1 does have an increased risk of sensitization to peanut at age 15 (OR=9.4, 95% CI 3.6-25.0). However, sensitization to peanut at age 2 has the greatest likelihood of persistence (OR=35.8, 95% CI 14.0-91.9). At age 15, 5.6% of those tested (18/322) had developed sensitization to peanut after age 7 while 3% (10/322) of those sensitized at age 7 to peanut were no longer skin test positive. Similarly from age 7 to 15, 1.6% (5/322) became sensitized to milk and 1.6% (5/322) became sensitized to egg. Food sensitization to milk, egg and peanut decrease over time. The greatest likelihood for persistent peanut sensitization is seen with a positive skin test at age 2. Risk factors for new sensitization and factors associated with the loss of sensitization need to be defined.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.001 | 0.003 |
| Science and technology studies | 0.002 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".