Synthesis and Characterization of Bis-bispidine-based Tetraazamacrocycles and Their Coordination Studies
Bibliographic record
Abstract
Bis-bispidine based tetraazamacrocycles can be used to encapsulate metal ions selectively to form highly stable complexes which may have interesting optical and electronic properties. This thesis discusses an effective synthetic pathway which has been used to obtain the desired bis-bispidine-based tetraazamacrocycles (Chapter 2). The synthesis of the macrocycles utilizes N -Boc- N -allylbispidinone 4 as the starting material which was subsequently converted to diketal bis(chloroacetamide) 8 and diketal bis(iodoacetamide) 9 . Cyclization of diketal bispidine hydrochloride 7 and bis(iodoacetamide) 9 followed by reduction afforded diketal bis-bispidine tetraazamacrocycle 12 . Cleavage of the ketal groups afforded a versatile bis-bispidinone substrate 13 which was further functionalized to diester 16 and bis-bispidine 17 . The desired bis-bispidine tetraazamacrocycle 17 was also obtained through another synthetic pathway which is discussed in Chapter 2. All the new compounds have been characterized by 1 H, 13 C NMR, IR, mass spectrometry and some by single crystal X-ray diffraction technique. Bis-bispidine-based tetraazamacrocycles have been used for coordination studies with metal ions under different reaction conditions and this is discussed in Chapter 3.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".