Phase-Amplitude Coupling Features Accurately Classify Multiple Sub-States Within a Seizure Episode
Bibliographic record
Abstract
Epilepsy is frequently characterized by convulsive seizures, which are often followed by a postictal EEG suppression state (PGES). The ability to automatically detect and monitor seizure progression and postictal state can allow for early warning of seizure onset, timely intervention in seizures themselves, as well as identification of major complications in epilepsy such as status epilepticus and sudden unexpected death in epilepsy (SUDEP). To test whether it is possible to reliably differentiate these ictal and postictal states, we investigated 52 seizure records (both intracranial and scalp EEG) from 19 patients. Phase-amplitude cross-frequency coupling was calculated for each recording and used as an input to a convolutional neural network model, achieving the mean accuracy of 0.890.09 across all classes, with the worst class accuracy of 0.73 for one of the later ictal sub-states. When the trained model was applied to SUDEP patient data, it classified seizure recordings as primarily interictal and PGES-like state (70% and 26%, respectively), highlighting the fact that in SUDEP patients seizures primarily exist in postictal states and don't show the ictal sub-state evolution. These results suggest that using frequency coupling markers with a machine learning algorithm can reliably identify ictal and postictal sub-states, which can open up opportunities for novel monitoring and management approaches in epilepsy.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".