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Record W4200309006 · doi:10.1016/j.gim.2021.11.008

Polygenic risk scores for prediction of breast cancer risk in Asian populations

2021· article· en· W4200309006 on OpenAlexaff
Weang-Kee Ho, Mei-Chee Tai, Joe Dennis, Xiang Shu, Jingmei Li, Peh Joo Ho, Iona Y. Millwood, Kuang Lin, Yon-Ho Jee, Su-Hyun Lee, Nasim Mavaddat, Manjeet K. Bolla, Qin Wang, Kyriaki Michailidou, Jirong Long, Eldarina Wijaya, Tiara Hassan, Kartini Rahmat, Veronique Kiak Mien Tan, Benita Kiat Tee Tan, Su Ming Tan, Ern Yu Tan, Swee Ho Lim, Yu‐Tang Gao, Ying Zheng, Daehee Kang, Ji‐Yeob Choi, Wonshik Han, Han‐Byoel Lee, Michiki Kubo, Yukinori Okada, Shinichi Namba, Sue K. Park, Sung-Won Kim, Chen‐Yang Shen, Pei‐Ei Wu, Boyoung Park, Kenneth Muir, Artitaya Lophatananon, Anna H. Wu, Chiu-Chen Tseng, Keitaro Matsuo, Hidemi Ito, Ava Kwong, Tsun Leung Chan, Esther M. John, Allison W. Kurian, Motoki Iwasaki, Taiki Yamaji, Sun-Seog Kweon, Kristan J. Aronson, Rachel A. Murphy, Woon‐Puay Koh, Chiea Chuen Khor, Jian‐Min Yuan, Rajkumar Dorajoo, Robin Walters, Zhengming Chen, Liming Li, Jun Lv, Keum Ji Jung, Peter Kraft, Paul D.B. Pharoah, Alison M. Dunning, Jacques Simard, Xiao‐Ou Shu, Cheng Har Yip, Nur Aishah Mohd Taib, Antonis C. Antoniou, Wei Zheng, Mikael Hartman, Douglas F. Easton, Soo‐Hwang Teo

Bibliographic record

VenueGenetics in Medicine · 2021
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenetic Associations and Epidemiology
Canadian institutionsUniversité LavalUniversity of British ColumbiaQueen's University
FundersMedical Research CouncilEuropean CommissionWellcome TrustBritish Heart FoundationNational Cancer InstituteCancer Research UK
KeywordsBreast cancerMedicineReceiver operating characteristicSingle-nucleotide polymorphismPopulation stratificationKappaHazard ratioStatisticsDemographyInternal medicineGenotypeConfidence intervalCancerGeneticsBiologyMathematics

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.024
Threshold uncertainty score0.416

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.023
GPT teacher head0.319
Teacher spread0.295 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations74
Published2021
Admission routes1
Has abstractno

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