MétaCan
Menu
Back to cohort
Record W4200357551 · doi:10.1002/elan.202100378

Electrochemical Characterization of the Repurposed Antimicrobial Compound Auranofin in Aqueous Solutions

2021· article· en· W4200357551 on OpenAlexafffund
Melak Yossief, Vikram Singh, Dustin Maydaniuk, Silvia T. Cardona, Sabine Kuss

Bibliographic record

VenueElectroanalysis · 2021
Typearticle
Languageen
FieldImmunology and Microbiology
TopicAntimicrobial Peptides and Activities
Canadian institutionsUniversity of WinnipegUniversity of Manitoba
FundersCanada Research Coordinating CommitteeUniversity of ManitobaResearch Manitoba
KeywordsAuranofinElectrochemistryCyclic voltammetryAqueous solutionVoltammetryChemistryRedoxCombinatorial chemistryNanotechnologyElectrodeMaterials scienceInorganic chemistryOrganic chemistryMedicine

Abstract

fetched live from OpenAlex

Abstract Electrochemical sensors are gaining attention for the detection and quantification of pharmaceuticals in the environment. To that end, there is an interest in understanding the electrochemical characteristics of drugs. Herein, the multi‐purpose drug auranofin is investigated for the first time in aqueous media. This compound offers therapeutic benefits in strains of cancer, parasites, bacteria and fungi, which have grown immune to many antibiotics. Auranofin detection was optimized at carbon black‐modified electrodes. Voltammetry provides information about redox potentials, levels of detection and quantification, and pH dependence. Parameters identified in this study will be useful for auranofin sensing in environmental samples, and for studies related to drug resistance.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.001
Threshold uncertainty score0.004

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0010.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.008
GPT teacher head0.201
Teacher spread0.193 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2021
Admission routes2
Has abstractyes

Explore more

Same venueElectroanalysisSame topicAntimicrobial Peptides and ActivitiesFrench-language works237,207