O24‐5: Altered megakaryocyte and platelet parameters in idiopathic pulmonary fibrosis
Bibliographic record
Abstract
were used to determine the prognostic significance of medication burden on transplant-free survival. Results: During the median follow-up of 2.5 years, 43% of IPF patients experienced adverse reactions leading to intolerance of antifibrotic medications within 6 months of initiation, with high baseline medication burden being an independent predictor of intolerance (medication count: p=0.02; polypharmacy: p=0.02; MRCI: p=0.01). This association was not observed for immunosuppressive medications in non-IPF ILD patients who had a lower rate of intolerability (18%). The MRCI was the only measure of medication burden that was associated with transplant-free survival in both cohorts (p<0.001 for both; Figure ), which improved prognostication beyond known clinical factors and the ILD-GAP index. Conclusions: Medication burden affects tolerance for antifibrotic medications in patients with IPF. Medication regimen complexity is superior to simple evaluation of medication burden for predicting prognosis in ILD.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".