Skeletal Muscle Pump Impairment in Parkinson's Disease: Preliminary Results
Bibliographic record
Abstract
The purpose of this study is to investigate if impairments in leg muscle contractions affect blood pressure (BP) regulation in patients with Parkinson's disease (PD). Simultaneous BP, electrocardiogram, and bilateral electromyogram (EMG) of the tibialis anterior, lateral and medial gastrocnemius, and soleus muscles were recorded from 16 patients with PD and 12 healthy controls in supine (5 minutes), head-up tilt test (15 minutes), and standing positions (5 minutes). Convergent Cross Mapping was used to examine the causal relationship of the muscle pump baroreflex <tex>$(SBP\rightarrow EMG_{imp})$</tex> and the effect of muscle activity on systolic blood pressure <tex>$(EMG_{imp}\rightarrow SBP)$</tex>. Preliminary results showed that PD participants have less effective lower leg skeletal muscle pump compared to the control group while no difference was found in the muscle pump baroreflex. Muscle pump causality was lower for all muscles in PD patients compared to the control group. Our data suggest that PD patients show a reduced causal effect of skeletal muscle pump on blood pressure. The obtained results also highlight the impairment of the ability of muscle pump to effectively control blood pressure in PD patients. The findings of this study can assist in the development of an effective system for monitoring orthostatic tolerance via muscle pump to prevent syncope and falls in PD.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".