The Unique Solution Structure and Immunochemistry of the <i>Candida albicans</i> β1, 2‐Mannopyranan Cell Wall Antigen
Bibliographic record
Abstract
This chapter contains sections titled: Introduction Candida albicans Cell Wall Host Defenses against Fungal Infection Chemical Synthesis of 1,2-Linked β-Mannopyranose Oligomers Synthesis of the Terminal Reducing Residue Synthesis of Oligosaccharides Synthesis of a (1 → 2)-β-Mannopyranotetrose Terminated by a Thio-glycosidic Linkage Molecular Modeling and NMR of (1 → 2)-β-Mannopyranan Tri-, Tetra- and Pentose Assignment of 1H and 13C Spectra for (1 → 2)-β-Mannopyranan Tri-, Tetra- and Pentose Oligomers Analysis of NOE Contacts for (1 → 2)-β-Mannopyranan Oligomers Molecular Dynamics Simulations Results of Trisaccharide Modeling Results of Tetrasaccharide Modeling Results of Pentasaccharide Modeling Conclusions about Molecular Modeling Conformational Analysis of the Thio-tetrasaccharide Analysis of the 1H and 13C NMR Spectra of Propyl β(1-2)-thio-tetramannopyranoside (6) Conformational Analysis of Thio-linked Tetrasaccharide 6 Comparison of the Native Tetrasaccharide with the Thioglycoside Mimetic Development of an Anti-Candida albicans Vaccine Synthesis of C. albicans Conjugate Vaccines Immunization of Experimental Animals Analysis of Antibody Levels Antibody Levels in Mice and Rabbits Binding of Propyl (1 → 2)-β-mannosides to Monoclonal Antibodies
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".