Decreased Adiponectin Levels Are a Risk Factor for Cognitive Decline in Spinal Cord Injury
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Objective. Spinal cord injury (SCI) has become popular in recent years, and cognitive decline is a common complication. Adiponectin is a common protein hormone involved in the course of many diseases, but its relationship with SCI has not yet been elucidated. The purpose of our prospective study is to explore whether adiponectin can be used as a biomarker of cognitive decline in SCI. Methods. A total of 64 healthy volunteers and 92 patients with acute SCI were recruited by us. Serum adiponectin levels, demographic data (age and gender), lifestyle (smoking and drinking), medical history (diabetes and hypertension), and clinical baseline data (low-density lipoprotein, high-density lipoprotein, and fasting blood glucose) were recorded. Three months after enrollment, we used the Montreal Cognitive Assessment (MoCA) to evaluate cognitive function. Based on a quarter of the serum adiponectin levels, SCI patients were divided into 4 groups, and the differences in their MoCA scores were compared. In addition, we used multivariate linear regression to predict the risk factors of the MoCA score. Results. The serum adiponectin level ( <math xmlns="http://www.w3.org/1998/Math/MathML" id="M1"> <mn>6.1</mn> <mo>±</mo> <mn>1.1</mn> <mtext> </mtext> <mi>μ</mi> <mtext>g</mtext> <mo>/</mo> <mtext>ml</mtext> </math> ) of SCI patients was significantly lower than that of the healthy control group ( <math xmlns="http://www.w3.org/1998/Math/MathML" id="M2"> <mn>6.7</mn> <mo>±</mo> <mn>0.9</mn> <mtext> </mtext> <mi>μ</mi> <mtext>g</mtext> <mo>/</mo> <mtext>ml</mtext> </math> ), and there was a significant difference between the two ( <math xmlns="http://www.w3.org/1998/Math/MathML" id="M3"> <mi>p</mi> <mo><</mo> <mn>0.001</mn> </math> ). The group with higher serum adiponectin levels after 3 months of spinal cord injury had higher MoCA scores. Multivariate regression analysis showed that serum adiponectin level is a protective factor for cognitive function after SCI ( <math xmlns="http://www.w3.org/1998/Math/MathML" id="M4"> <mi>β</mi> <mo>=</mo> <mn>0.210</mn> </math> , <math xmlns="http://www.w3.org/1998/Math/MathML" id="M5"> <mi>p</mi> <mo>=</mo> <mn>0.043</mn> </math> ). Conclusions. Serum adiponectin levels can be used as an independent predictor of cognitive function in patients with acute SCI.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.005 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it